I tried SAMe to benefit my liver because of all the “cyano” I was getting from the increased number of cyanocobalamin B12 shots my doctor prescribed after I had tetanus, and, because of my extended exposure to hydrogen sulfide. (I had felt that my liver was probably overworked.)
I tried SAMe after I was told that it gets rid of toxins. Happily, it seemed to help, so I put this information here.
WARNING: The SAMe directions say to take on an empty stomach, which I have always done, with several ounces of water. But on Tuesday I took it with coffee, and within an hour I was getting sick. Within three hours I felt as if I had food poisoning, but I hadn’t eaten anything. I have been very sick for two days, and yesterday was well enough to get my reading glasses so I could read the box. It does say that for some people it can cause gastrointestinal upset, and if it does, to discontinue taking it. I am very sad to have to stop taking it, as it had seemed to be helping. I am very sad I took it with coffee. 6/8/06
A powerful, natural nutrient, S-adenosyl-methionine (SAM-e) promotes healthy mood, liver and joint function. Numerous studies going back two decades, including a 2002 study sponsored by the U.S. Department of Health and Human Resources (HHS), show that SAM-e is quite safe and effective for promoting healthy mood and liver function, as well as joint function.
Higher SAM-e levels in the brain are associated with successful improvement of mood. While not as powerful as antidepressants, a study published in the Journal of Psychiatric Research showed that SAM-e takes effect within one week, quicker than that of drug antidepressants. And unlike antidepressants, SAM-e does not lead to such typical side effects as weight gain, headaches, and sexual dysfunction.
Studies published in the American Journal of Medicine show that SAM-e may benefit joint health, improving joint function and reducing pain. In the liver, SAM-e has been shown to improve the flow of bile and replenish important antioxidants. A double-blind study concerning muscle health published in the Scandinavian Journal of Rheumatology showed that 800 mg daily of SAM-e supplementation for six weeks resulted in reduced pain, fatigue, and stiffness, and improved mood.
The typical SAM-e dosage is 400-800 mg daily for promoting a healthy mood, liver and joints.