NSAIDS and Malabsorption

NSAIDS can damage your stomach making it more hospitable to h.pylori and less hospitable to vitamin and mineral absorption, particularly in the case of vitamin B12 and magnesium. When your stomach lining is damaged h.pylori sees the damage as an invitation to burrow in. The more h.pylori you have the less stomach acid your stomach can produce and without adequate stomach acid you can’t release B12 and magnesium from the food you eat, even if the food is rich in them. h.pylori ~ Read more.

7/25/2015 ~ I’ve used a lot of Ibuprofen over the years. When I learned about Serrapeptase I began using Serrapeptase and found I needed far less Ibuprofen, nevertheless I still use one or two Ibuprofen a day. But given what I’ve learned, that must change.

Serrapeptase ~ Read more.

Merck has the following to say about NSAIDS (non-steroidal anti-inflammatory drugs), which include Ibuprofen:

“NSAIDs promote mucosal inflammation and ulcer formation (sometimes with GI bleeding) both topically and systemically.”

Because NSAIDs like Ibuprofen reduce Prostaglandin production, you need to know a little about Prostaglandins in order to understand what is being inhibited by NSAIDs.

Prostaglandins are fatty acid compounds with hormone like effects. The two main Prostaglandins or fatty acid compounds are powerful, locally acting vasodilators. That is, they widen blood vessels by relaxing smooth muscle cells in vessel walls. Relaxed smooth muscle cells and the better blood flow that goes with them contribute to reducing inflammation.

Some Prostaglandin fatty acid compounds inhibit blood clotting. Ischemic strokes happen when a blood clot (thrombus) or a fatty deposit blocks an artery supplying blood to the brain. Given that strokes run in my family I’m shocked that I didn’t know I was courting a stroke by using so much Ibuprofen.

When you aren’t using NSAIDS, the walls of your blood vessels happily synthesize adequate amounts of these essential fatty acid compounds which function in preventing dangerous clots. Interestingly, the same prostaglandin may stimulate a reaction in one tissue and inhibit the same reaction in another tissue. The effect of these important fatty acid compounds is determined by the type of receptor to which they bind.

Even this minimal prostaglandin background shows that by decreasing prostaglandin production, NSAIDs reduce gastric blood flow. Less blood flow reduces HCO 3 (bicarbonate) secretion and decreases cell repair and replication. Thus, the more Ibuprofen you use, the more Tums you need in order to make up for the decrease in natural bicarbonate production.

Because NSAIDs are weak acids and are non-ionized at gastric pH, they diffuse freely across the mucus barrier into gastric epithelial cells, where H+ ions are liberated, leading to cellular damage. To avoid this problem some NSAIDS have been developed that produce fewer adverse stomach problems. However, the NSAIDs that result in fewer gastric ulcers tend to result in more heart attacks and strokes, as were seen with the use of Vioxx which was taken off the market after 27,000 adverse reactions to include deaths.

NSAIDs and H. pylori disrupt normal mucosal defense and repair, making the mucosa more susceptible to acid. H. pylori infection (see Helicobacter pylori Infection) is present in 50 to 70% of patients with duodenal ulcers and 30 to 50% of patients with gastric ulcers. If H. pylori is eradicated, only 10% of patients have recurrence of peptic ulcer disease, compared with 70% recurrence in patients treated with acid suppression alone. NSAIDs now account for > 50% of peptic ulcers.

Merck Professional Manual on NSAIDS ~ Read more.

7/31/2015 ~ I forget whether I stopped using Ibuprofen the day I began this page, or the next day, but I have stopped.

Except, that other articles linked lower rates of Parkinson Disease with Ibuprofen use. So, when I find myself trembling from the stress of dealing with Wells Fargo’s foreclosure action (since they didn’t serve me, which is a denial of due process, everything Wells Fargo does now makes me uneasy, as if there’s some element of trap in it) I take an Ibuprofen and find the trembling stops.

Additionally, I now make it a point to walk around my garden, which is about the same distance as a lap in an Olympic sized pool, in the morning. That stimulates my metabolism and it limbers up my muscles. I also walk the entire length of my house a couple times when I go to or from the kitchen. My house isn’t large, but the additional distance, again about the size of a big swimming pool, increases my circulation and overall I had less pain or discomfort of any kind yesterday afternoon than in at least a year.

I also ordered bulbs for my salt lamp because of the research I did that shows negative ions, like those produced by Epsom salt baths, pine forests, thunderstorms, heated salt lamps, etc. reduce Serotonin levels and the way that Serotonin increases the sensation of pain. (I’m not sure I should leave it on overnight. It seemed to make me feel less sleepy, or, I could simply have been excited about it.)

Negative ions ~ Read more.

Summary
NSAIDS and Malabsorption
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NSAIDS and Malabsorption
Description
NSAIDs are weak acids that disrupt normal mucosal defense/repair in the stomach. They reduce vitamin and mineral absorption and account for 50% of peptic ulcers
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Health Boundaries
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