NSAIDS and Malabsorption

7/25/2015 ~ I have used a lot of Ibuprofen over the years. When I learned about Serrapeptase I began using it and found I needed far less Ibuprofen, nevertheless I still use one or two Ibuprofen a day. But given what I’ve learned, that must change.

Serrapeptase ~ Read more.

Merck has the following to say about NSAIDS (non-steroidal anti-inflammatory drugs), which include Ibuprofen:

“NSAIDs promote mucosal inflammation and ulcer formation (sometimes with GI bleeding) both topically and systemically.”

Because NSAIDs like Ibuprofen reduce Prostaglandin production, you need to know a little about Prostaglandins in order to understand what is being inhibited by NSAIDs.

The two main Prostaglandins are powerful, locally acting vasodilators. That is, they widen blood vessels by relaxing smooth muscle cells in vessel walls.

Prostaglandins also inhibit the aggregation of blood platelets, i.e. they inhibit blood clotting. Ischemic strokes happen when a blood clot (thrombus) or a fatty deposit blocks an artery supplying blood to the brain. Given that strokes run in my family I’m shocked that I didn’t know I was courting a stroke by using so much Ibuprofen.

Prostaglandins, via their role in vasodilation, are also involved in controlling inflammation.

The walls of your blood vessels synthesize Prostaglandins which serve the physiological function of preventing needless and sometimes dangerous clot formation. Interestingly, the same prostaglandin may stimulate a reaction in one tissue and inhibit the same reaction in another tissue. The effect of the Prostaglandin is determined by the type of receptor to which the prostaglandin binds.

With the above background understanding, you can see why it’s important to know that by decreasing prostaglandin production, NSAIDs reduce gastric blood flow, reduce mucus and HCO 3 (bicarbonate) secretion, and decrease cell repair and replication. Thus it appears that the more Ibuprofen you use, the more Tums you may feel it necessary to use in order to make up for the decrease in natural bicarbonate production.

Because NSAIDs are weak acids and are nonionized at gastric pH, they diffuse freely across the mucus barrier into gastric epithelial cells, where H + ions are liberated, leading to cellular damage. Because gastric prostaglandin production involves the COX-1 isoform, NSAIDs that are selective COX-2 inhibitors have fewer adverse gastric effects than other NSAIDs. (Long words aside, I think this paragraph is clear and best not paraphrased.)

Significantly, the same NSAIDs that result in fewer gastric ulcers tend to result in more heart attacks and strokes, as were seen with the use of Vioxx which was taken off the market after 27,000 adverse reactions to include deaths.

NSAIDs and H. pylori disrupt normal mucosal defense and repair, making the mucosa more susceptible to acid.H. pylori infection (see Helicobacter pylori Infection) is present in 50 to 70% of patients with duodenal ulcers and 30 to 50% of patients with gastric ulcers. If H. pylori is eradicated, only 10% of patients have recurrence of peptic ulcer disease, compared with 70% recurrence in patients treated with acid suppression alone. NSAIDs now account for > 50% of peptic ulcers.

Merck Professional Manual on NSAIDS ~ Read more.

7/31/2015 ~ I forget whether I stopped using Ibuprofen the day I began this page, or the next day, but I have stopped.

Except, that other articles linked lower rates of Parkinson Disease with Ibuprofen use. So, when I find myself trembling from the stress of dealing with Wells Fargo’s foreclosure action (since they didn’t serve me, which is a denial of due process, everything Wells Fargo does now makes me uneasy, as if there’s some element of trap in it) I take an Ibuprofen and find the trembling stops.

Additionally, I now make it a point to walk around my garden, which is about the same distance as a lap in an Olympic sized pool, in the morning. That stimulates my metabolism and it limbers up my muscles. I also walk the entire length of my house a couple times when I go to or from the kitchen. My house isn’t large, but the additional distance, again about the size of a big swimming pool, increases my circulation and overall I had less pain or discomfort of any kind yesterday afternoon than in at least a year.

I also ordered bulbs for my salt lamp because of the research I did that shows negative ions, like those produced by Epsom salt baths, pine forests, thunderstorms, heated salt lamps, etc. reduce Serotonin levels and the way that Serotonin increases the sensation of pain. (I’m not sure I should leave it on overnight. It seemed to make me feel less sleepy, or, I could simply have been excited about it.)

Negative ions ~ Read more.

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